ABSTRACT
Background:Anthracycline antibiotics are potent antineoplastic agents. Unfortunately, despite its broad effectiveness, anthracycline therapy is associated with irreversible dilated cardiomyopathy. Toxic effect may occur at any stage of anthracycline treatment. When it takes place, medical therapy is mostly insufficient. Therefore, prevention of cardiomyopathy has great clinical importance. This study aimed at evaluating the protective effect of carvedilol against anthracycline-induced cardiomyopathy on patients with breast cancer and lymphoma.Methods: In a randomized clinical trial, 66 patients with breast cancer or lymphoma selected for chemotherapy in Tabriz city hospital. These patients randomized in three groups; the first group (control) received placebo; the second group (A) received carvedilol 6.25mg/d and the third group (B) received carvedilol 12.5mg/d for 4months. Conventional echocardiography and tissue Doppler study were employed for evaluating the patients on the baseline and at the end of survey.Results:At the end of 4 months of follow-up, 1 (4.5%) patient in group B, 2 (9.1%) patients in group A and 4 (18.2%) patients of the control group had died. Clinical systolic dysfunction was encountered in 5 (27.8%), 5 (25%) and 1 (4.8%) patients in the control, A and B groups, respectively. A distinctive clinical diastolic dysfunction was encountered in 5 (27.8%), 3 (15%) and 3 (14.3%) patients in the control, A and B groups, respectively. Carvedilol with a dose of 6.25mg/d prohibited the diastolic dysfunction at the end of study without a significant effect on the prevention of diastolic dysfunction. Carvedilol with a dose of 12.5mg/d effectively prevented both the systolic and diastolic dysfunctions at the end of study.Conclusions:The current study showed that prophylactic administration of carvedilol with a dose of 12.5 mg/d might significantly prevent the systolic and diastolic dysfunction of the left ventricle in patients receiving chemotherapy with anthracycline
ABSTRACT
Meat products may be unacceptably tough because of the high connective tissue content of meats used in their manufacture. The aim of this study was using meat acid marination method on some physicochemical and sensory characteristics of beef burgers. Meat was marinated in three concentrations [0.5%, 1% and 1.5%] of lactic and citric acid solutions [1:4 w/v] at 4 °C for 15h and was used in formulation of beef burgers. According to control sample, the highest redness [a[*] value was found in the lowest concentration of lactic acid while the lowest a[*] value was in the highest concentration of citric acid. Shear force value indicated that lactic acid had a tenderizing effect particularly at the lowest concentration and had a positive effect on overall acceptability. Electrophoresis of proteins showed that band intensity had decreased in 0.5% acid treatments, compared to the control sample. It seems that meat acid marination is an applicable technique to tenderize beef burgers with high percentage of meat
ABSTRACT
Copper and zinc are the elements with numerous physiological activities. Copper [Cu] has an important role in angiogenesis and acts by increasing Vascular Endothelial Growth Factor [VEGF]. Serum levels of copper will be increased in cancer incidence, progression and recurrence. The aim of this study was to measure blood levels of copper, zinc, and the ratio of Cu /Zn, as well as VEGF levels before and after treatment of acute myeloid leukemia. Thirty patients who were recently diagnosed with Acute Myeloblastic Leukemia [AML] in Shahid Ghazi Tabatabai oncology hospital enrolled in this clinical trial. On the first day, blood samples were taken for copper, zinc, and VEGF assay and flowcytometry. Treatment protocol was [7x3] regimen. Blood samples were collected for evaluation of copper, zinc, and VEGF. They were sent to Biochemistry Laboratory in medicine faculty for analysis. Amongst 30 AML patients, 14 [46.7%] were female and 16 [53.3%] were male. Patients of various ages ranged from 16 to 53 years, with a median age of 9.1 +/- 9.35 years. The mean serum level of copper, zinc, and mean Cu/Zn ratio before and after treatment showed significant difference [p<0.05] There was also significant difference between the mean VEGF level before and after treatment [p<0.05]. This study reveals that there is no significant relationship between copper, zinc serum levels, their ratio, and VEGF in AML patients. We hypothesize that increased serum copper is associated with increase of VEGF levels which can indicate the impact of copper in malignancies including AML
ABSTRACT
Background: soldiers are a healthy population but they are at risk for diseases. The aim of this study was evaluation of behavior predispose to dieses related to elongation of in service time
Materials and methods: this study is a cross-sectional that randomly performed in one thousands of soldier's in capital city of Iran in 2006.demography data contain age, education level, long of in-service, smoking, addiction, tattooing, sexual contact. These data were analyzed with spss13 and used of t-test and chi-square
Results: all soldiers were man with mean age 21.5 +/-1.8 years old. This study showed that 92[10.2%] had less than one year, 18[2%] had more than two year and other had between 1-2years in-service. soldiers with more than two year in service 14[7.6%] had common teeth broth, 11[61.1%] had smoking, 6[33.3%] had history of addiction, 5[29.4%] had sexuality contact and more of these variants had related directly to long of in-service
Conclusion: this study showed that high risk behavior was high in soldiers with more than two years in-service. For this reason we considered to further health education for them
ABSTRACT
Cutaneous Leishmaniasis caused by a parasite called Leishmania. Leishmaniasis is a main vector borne disease in the world and it can be transmitted to human by bite of sandflies. Cutaneous Leishmaniasis was a major infectious disease during imposed war among combatants who were exposed because of their activity in the endemic areas located in south west of Iran. Military troops are very susceptible to get the infection as a result of their activity in the endemic areas, therefore the Integrated Health measures are needed to prevent the problem. The aim of this descriptive study was to assess the situation of the disease during imposed war. This descriptive and cross-sectional study was carried out in order to find out the situation of the disease by using available data from 1980 to 1988.The data was analysed using SPSS Version 11.5. In addition, the result was compared with other National Health Organizations. Based on these research findings, it should be noted that cutaneaous leishmaniasis was very common among conbataouts in Kozestan, the province with the highest prevalence [35275 cases]. However, the west Azarbijan province in North west of Iran had low prevalence of infection [142 cases]. Nevertheless, the disease has never been reported in Ardebil [North west of Iran] and Ghom [in the central of Iran] during imposed war. The results of this study indicated that cutaneous Leishmaniasis was a major problem of combatant during imposed war, and its definitive control was ineffective and insufficient; therefore, the new control methods including Standard Leishmanization are needed to prevent the disease
Subject(s)
Humans , Leishmaniasis, Cutaneous/epidemiology , Leishmaniasis, Cutaneous/prevention & control , Psychodidae , Armed Conflicts , Military PersonnelABSTRACT
Background: Cutaneous Leishmaniasis caused by a parasite called Leishmania. Leishmaniasis is a main vector borne disease in the world and it can be transmitted to human by bite of sandflies. Cutaneous Leishmaniasis was a major infectious disease during imposed war among combatants who were exposed because of their activity in the endemic areas located in south west of Iran. Military troops are very susceptible to get the infection as a result of their activity in the endemic areas, therefore the Integrated Health measures are needed to prevent the problem. The aim of this descriptive study was to assess the situation of the disease during imposed war
Materials and Methods: This descriptive and cross-sectional study was carried out in order to find out the situation of the disease by using available data from 1980 to 1988. The data was analyses using SPSS Version 11.5. In addition, the result was compared with other National Health Organizations
Results: Based on these research findings, it should be noted that cutaneaous leishmaniasis was very common among conbataouts in Kozestan, the province with the highestprevalence [35275 cases]; However, the west Azarbijan province in North west of Iran had low prevalence of infection [142 cases]; Nevertheless, the disease has never been reported in Ardebil [North west of Iran] and Ghom [in the central of Iran] during imposed war
Conclusions: The results of this study indicated that cutaneous Leishmaniasis was a major problem of combatant during imposed war, and its definitive control was ineffective and insufficient; therefore, The new control methods including Standard Leishmanization are needed to prevent the disease
ABSTRACT
Background: The purpose of this study was to evaluate the effect of treatment with radioactive iodine on the function of gonads in males and females with follicular and papillary thyroid carcinoma
Materials and Methods: Consenting patients in the reproductive age were grouped according to the cumulative dose of received radioiodine and followed for at least 12 months. For all men, serum levels of FSH, LH, and testosterone were measured some [53 cases] were also studied by semen analysis. For women, tests for serum levels of LH, FSH, estrogen, and progesterone were performed
Results: Overall, 246 patients [159 females, 87 males] were studied. In 87.4% of men, there was an increase in serum FSH level after radioiodine therapy, in 20.7% of whom the level remained high during follow-up period. The average serum level of FSH after each course of treatment was significantly higher than the level before treatment [p<0.01], and there was a meaningful correlation with the cumulative dose of received iodine [p<0.001]. Reduced number of sperms was shown in 35.8% of male patients, among whom 73.7% also showed reduced motility. In 36.8% of the patients with reduced sperm number [13.2% of the total], this finding was persistent during the follow-up period. Increased level of FSH was correlated with reduced sperm counts in all doses [p<0.005]. There was no significant correlation between serum levels of LH and testosterone with iodine treatment in males [p=0.47]. In women, no significant correlation between gonadal-hypophyseal hormones and treatment with radioactive iodine was found, and there were no signs and symptoms of sexual dysfunction. Infertility was not noticed in any patient and no case of abortion was found
Conclusion: It seems that cells in spermatogonia lineage [in contrast to Leydig cells] are radiosensitive, with the sensitivity related to the cumulative dose of received radioactive iodine. But in the oogonia cell line, the radiosensitivity is insignificant
ABSTRACT
The production of nitric oxide [NO] is important in the final outcome of leishmaniasis in animal models. The efficacy of garlic therapy and a combination of garlic and vitamin A were compared with an antimonial drug [glucantime] to assess healing and regulation of NO release in mice infected with Leishmania major. The mice were subjected to 3 105 promastigotes and allowed to induce a lesion. The mice were treated with above compounds twice a day for 45 days. The diameter of the lesion was measured on days 1, 10, 20, 30 and 45. In a separate experiment, NO release by peritoneal macrophages was measured. The diameter of lesion was reduced by aqueous extract of garlic within 30 days of treatment. However, the maximum reduction was induced when mice were subjected to vitamin A for 10 days before the administration of the aqueous extract for 30 days. A significant correlation between healing and the amount of NO release was also found. A combination of aqueous extract of garlic and vitamin A can treat leishmanisis